Analytical Data
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基因名
APRIN
- Application
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别名
PDS5B; APRIN; AS3; KIAA0979; Sister chromatid cohesion Protein PDS5 homolog B; Androgen-induced proliferation inhibitor; Androgen-induced prostate proliferative shutoff-associated Protein AS3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NTI5
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表达区间
1168- 1259aa
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氨基酸序列
GRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKRDDSDLVRSELEKPRGRKKTPVTEQEEKLGMDDLTKLVQEQKPKGSQRSRKRGHTASES
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分子量
35.86 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APRIN (APC-C1-2-related protein) is a recently identified protein that has gained attention in the field of cellular biology due to its potential roles in cell cycle regulation and genomic stability. Research into APRIN's structure and function has revealed its involvement in the regulation of the anaphase-promoting complex/cyclosome (APC/C), a crucial E3 ubiquitin ligase that governs the transition from metaphase to anaphase during cell division. Aberrant regulation of the APC/C has been linked to various cancers and other diseases, making APRIN a significant target for understanding the mechanisms of tumorigenesis. Furthermore, studies utilizing recombinant APRIN protein have shed light on its mechanisms of action, potential interactions with other cell cycle regulators, and its role in DNA damage response pathways. Understanding the precise function and regulation of APRIN could pave the way for the development of novel therapeutic strategies aimed at manipulating the cell cycle in cancer treatment and improving genomic integrity in a range of biological contexts. These insights position APRIN as a valuable subject of study, with implications extending beyond basic biology into clinical applications.
