Analytical Data
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Gene name
APRIN
- Application
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Alternative Names
PDS5B; APRIN; AS3; KIAA0979; Sister chromatid cohesion Protein PDS5 homolog B; Androgen-induced proliferation inhibitor; Androgen-induced prostate proliferative shutoff-associated Protein AS3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NTI5
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Expression Region
1168- 1259aa
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AA Sequence
GRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKRDDSDLVRSELEKPRGRKKTPVTEQEEKLGMDDLTKLVQEQKPKGSQRSRKRGHTASES
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Molecular Weight
35.86 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
APRIN (APC-C1-2-related protein) is a recently identified protein that has gained attention in the field of cellular biology due to its potential roles in cell cycle regulation and genomic stability. Research into APRIN's structure and function has revealed its involvement in the regulation of the anaphase-promoting complex/cyclosome (APC/C), a crucial E3 ubiquitin ligase that governs the transition from metaphase to anaphase during cell division. Aberrant regulation of the APC/C has been linked to various cancers and other diseases, making APRIN a significant target for understanding the mechanisms of tumorigenesis. Furthermore, studies utilizing recombinant APRIN protein have shed light on its mechanisms of action, potential interactions with other cell cycle regulators, and its role in DNA damage response pathways. Understanding the precise function and regulation of APRIN could pave the way for the development of novel therapeutic strategies aimed at manipulating the cell cycle in cancer treatment and improving genomic integrity in a range of biological contexts. These insights position APRIN as a valuable subject of study, with implications extending beyond basic biology into clinical applications.











