Analytical Data
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基因名
ORC6L
- Application
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别名
ORC 6; Orc6; ORC6_HUMAN; ORC6L; Origin recognition complex subunit 6; origin recognition complex subunit 6 homolog like; origin recognition complex subunit 6 homolog like (yeast); origin recognition complex subunit 6 like (yeast)
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5N6
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表达区间
1-252 aa
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氨基酸序列
MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKILENAASAQKATAE
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分子量
55.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ORC6L, or the Origin Recognition Complex Protein 6 Like, is a crucial component of the origin recognition complex (ORC), which plays a vital role in the initiation of DNA replication. Understanding the function and regulation of ORC6L is significant because proper DNA replication is essential for cell division and growth. Dysregulation of the proteins involved in this process can lead to various diseases, including cancer. Recent studies have highlighted ORC6L's role not only in maintaining genomic stability but also in influencing cellular responses to DNA damage and stress. Furthermore, ORC6L's interactions with other proteins suggest its involvement in several cellular pathways beyond replication, making it a potential target for therapeutic interventions. As researchers delve deeper into the molecular mechanisms governing ORC6L’s functions, they aim to uncover its distinct roles in both normal physiology and disease states, thereby offering insights that could lead to novel cancer therapies and improved understanding of cell cycle regulation. Overall, the study of ORC6L and its associated pathways represents a vital area of research in molecular biology and cancer therapeutics.
