Analytical Data
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Gene name
TIRAP
- Application
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Alternative Names
TIRAP；MAL；Toll/interleukin-1 receptor domain-containing adapter Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P58753
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Expression Region
1-221aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMASSTSL PAPGSRPKKP LGKMADWFRQ TLLKKPKKRP NSPESTSSDA SQPTSQDSPL PPSLSSVTSP SLPPTHASDS GSSRWSKDYD VCVCHSEEDL VAAQDLVSYL EGSTASLRCF LQLRDATPGG AIVSELCQAL SSSHCRVLLI TPGFLQDPWC KYQMLQALTE APGAEGCTIP LLSGLSRAAY PPELRFMYYV DGRGPDGGFR QVKEAVMRYL QTLS
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TIRAP (Toll-interleukin 1 receptor (TIR) domain-containing adapter protein), also known as MyD88-adapter-like (Mal), is a crucial component of the Toll-like receptor (TLR) signaling pathway, which plays a significant role in the innate immune response. TIRAP acts as a bridge between the TLRs and various downstream signaling molecules, facilitating the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and other transcription factors that regulate immune responses. Research into TIRAP has gained momentum due to its involvement in mediating the host defense against pathogens and its potential implications in various diseases, including infections, inflammatory disorders, and autoimmune conditions. Understanding the structure and function of TIRAP can provide insights into the mechanisms of immune signaling and pave the way for therapeutic interventions. Recent studies have focused on the recombinant expression and purification of TIRAP to explore its functional properties and interactions with other proteins. Furthermore, the investigation of TIRAP's role in modulating inflammation and its potential as a target for drug development highlights its significance in immunology. Overall, TIRAP recombinant protein research holds promise for advancing our understanding of innate immunity and developing novel therapeutic strategies to combat immune-related diseases.
