Analytical Data
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基因名
UA
- Application
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别名
UA；U2AF65；Splicing factor U2AF 65 kDa subunit
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13838
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表达区间
2-251aa
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氨基酸序列
AENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFV
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分子量
55.2kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UA (Urokinase-type plasminogen activator) recombinant proteins have gained significant attention in biomedical research due to their pivotal role in various physiological and pathological processes, particularly in fibrinolysis, wound healing, and tissue remodeling. Urokinase is an enzyme that catalyzes the conversion of plasminogen to plasmin, the latter being essential for the breakdown of fibrin in blood clots. Dysregulation of this pathway is associated with numerous conditions, including cardiovascular diseases, cancer metastasis, and inflammatory disorders. As a result, the development of UA recombinant proteins offers promising therapeutic applications, such as in the treatment of thromboembolic disorders and enhancing tissue regeneration. Researchers have been exploring the optimization of expression systems for the production of these proteins, including bacterial, yeast, and mammalian cell systems, to enhance yield, functionality, and safety for clinical use. Furthermore, advancements in genetic engineering and protein purification techniques have facilitated the creation of more effective UA variants with tailored properties for specific medical applications. The growing understanding of UA's biological mechanisms and its interactions with other molecules has also opened avenues for novel drug design and targeted therapies, making UA recombinant proteins a focal point of ongoing research aimed at improving patient outcomes in various diseases. Overall, the study of UA recombinant proteins is a dynamic field that bridges molecular biology and clinical medicine, highlighting the potential for innovative treatments derived from recombinant biotechnology.
