Analytical Data
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Gene name
C4d
- Application
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Alternative Names
C4d；CO4；CPAMD2；Complement C4-A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P0C0L4
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Expression Region
957-1336aa
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AA Sequence
MASMTGGQQMGRGHHHHHHGNLYFQGGEFTLEIPGNSDPNMIPDGDFNSY VRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRY LDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRDSSTW LTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQDPCPVLDRS MQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKANS FLGEKASAGLLGAHAAAITAYALTLTKAPVDLLGVAHNNLMAMAQETGDN LYWGSVTGSQSNAVSPTPAPRNPSDPMPQAPALWIETTAYALLHLLLHEG KAEMADQASAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASHTTEERGL NVTLSSTGR
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Molecular Weight
44 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C4d, a specific fragment of complement component 4 (C4), is recognized as a significant biomarker in the context of immune-mediated diseases and organ transplantation. Its formation is an indicator of complement activation, particularly in conditions where the immune system is dysregulated. The study of C4d has gained momentum due to its crucial role in diagnosing and monitoring transplant rejection, especially in kidney and heart transplants. Elevated levels of C4d in the tissue of transplanted organs correlate with antibody-mediated rejection, providing insights into the underlying mechanisms of graft dysfunction. Moreover, C4d is being investigated as a potential therapeutic target, with research focusing on strategies to modulate complement activation to improve transplant outcomes and manage various autoimmune diseases. By understanding the biochemical pathways and physiological implications of C4d accumulation, researchers hope to develop innovative approaches for enhancing graft survival and reducing the incidence of rejection episodes. This growing body of research underscores the importance of C4d not just as a biomarker but also as a pivotal player in the intricate interplay between the immune system and transplant biology.
