Analytical Data
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Gene name
SNURF
- Application
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Alternative Names
RNF4;SNURF;E3 ubiquitin-Protein ligase RNF4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y675
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Expression Region
1-71aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMERARDR LHLRRTTEQH VPEVEVQVKR RRTASLSNQE CQLYPRRSQQ QQVPVVDFQA ELRQAFLAET PRGG
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Molecular Weight
11 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SNURF (Small Nuclear RNA Ubiquitin-Related Factor) is a protein encoded by the SNURF gene, which has been implicated in various biological processes, particularly in gene regulation and the ubiquitin-proteasome system. Research on SNURF began to gain momentum due to its association with Prader-Willi syndrome (PWS) and its potential role in neurological functions. Prader-Willi syndrome is a complex genetic disorder caused by the loss of function of paternal alleles within the 15q11-q13 genomic region, where SNURF is located. The unique expression pattern and functional characteristics of SNURF have sparked interest in understanding its mechanisms, as they may contribute to the phenotype observed in PWS patients. Insights into SNURF also offer potential therapeutic avenues for modulating gene expression in various disorders. Recent studies have focused on the structural and functional properties of SNURF, exploring its interactions with other molecular players and its regulatory roles. By employing techniques such as recombinant protein production, researchers aim to elucidate the functional dynamics of SNURF and its involvement in diseases, which could lead to novel interventions and a deeper understanding of genetic regulation involving imprinted genes. This research highlights the importance of SNURF not only in PWS but also in broader contexts of gene expression and cellular homeostasis.
