Analytical Data
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基因名
FOXE3
- Application
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别名
FOXE3；FKHL12；FREAC8；Forkhead box Protein E3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13461
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表达区间
1-319aa
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氨基酸序列
MAGRSDMDPP AAFSGFPALP AVAPSGPPPS PLAGAEPGRE PEEAAAGRGE AAPTPAPGPG RRRRRPLQRG KPPYSYIALI AMALAHAPGR RLTLAAIYRF ITERFAFYRD SPRKWQNSIR HNLTLNDCFV KVPREPGNPG KGNYWTLDPA AADMFDNGSF LRRRKRFKRA ELPAHAAAAP GPPLPFPYAP YAPAPGPALL VPPPSAGPGP SPPARLFSVD SLVNLQPELA GLGAPEPPCC AAPDAAAAAF PPCAAAASPP LYSQVPDRLV LPATRPGPGP LPAEPLLALA GPAAALGPLS PGEAYLRQPG FASGLERYL
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分子量
33.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOXE3 (Forkhead box E3) is a pivotal transcription factor that plays a critical role in the development and function of various tissues, particularly in the thyroid and lens of the eye. Research has shown that FOXE3 is essential for the proper regulation of genes involved in thyroid hormone production and eye lens transparency. Mutations or dysregulations in the FOXE3 gene have been linked to congenital hypothyroidism and specific eye disorders, including cataracts. The recombinant FOXE3 protein serves as a vital tool for studying its functional mechanisms in both developmental biology and disease pathogenesis. Through techniques such as recombinant DNA technology, scientists can produce FOXE3 in controlled laboratory settings, allowing for in-depth analysis of its interactions with other proteins and its role in gene expression regulation. This recombinant approach facilitates the exploration of FOXE3's potential as a therapeutic target, aiming to develop interventions for diseases stemming from its dysfunction. Overall, the study of FOXE3 and its recombinant protein forms a crucial area of research with implications for understanding thyroid and ocular health.
