Analytical Data
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Gene name
ATPIF1
- Application
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Alternative Names
ATPIF1；ATPI；ATPIF1；ATPase inhibitor. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UII2
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Expression Region
26-106aa
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AA Sequence
GSDQS ENVDRGAGSI REAGGAFGKR EQAEEERYFR AQSREQLAAL KKHHEEEIVH HKKEIERLQK EIERHKQKIK MLKHDD
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Molecular Weight
12.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATPIF1 (ATP Inhibitory Factor 1) is a regulatory protein that plays a crucial role in mitochondrial bioenergetics and cellular metabolism. It is known to interact with ATP synthase, the enzyme responsible for ATP production in mitochondria, by inhibiting its activity under certain conditions, such as increased mitochondrial membrane potential or high ATP levels. Research on ATPIF1 has gained importance due to its potential implications in various physiological and pathological processes. Abnormal regulation of ATPIF1 has been linked to several diseases, including neurodegenerative disorders, cancer, and metabolic syndromes, where altered energy metabolism is a hallmark. Understanding the molecular mechanisms underlying ATPIF1's function can provide insights into mitochondrial dynamics and bioenergetics, paving the way for potential therapeutic strategies. Furthermore, recombinant expression of ATPIF1 enables detailed biochemical and structural studies, facilitating the exploration of its role in energy regulation and its interactions with other mitochondrial proteins. The research on ATPIF1 is vital for elucidating its contribution to overall cellular homeostasis and mitochondrial health, as well as its potential as a target for drug development aimed at restoring normal metabolic function in various diseases.
