Analytical Data
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Gene name
NSMCE4A
- Application
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Alternative Names
NSMCE4A; C10orf86; PP4762; Non-structural maintenance of chromosomes element 4 homolog A; NS4EA; Non-SMC element 4 homolog A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NXX6
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Expression Region
1-385 aa
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AA Sequence
MSGDSSGRGP EGRGRGRDPH RDRTRSRSRS RSPLSPRSRR GSARERREAP ERPSLEDTEP SDSGDEMMDP ASLEAEADQG LCRQIRHQYR ALINSVQQNR EDILNAGDKL TEVLEEANTL FNEVSRAREA VLDAHFLVLA SDLGKEKAKQ LRSDLSSFDM LRYVETLLTH MGVNPLEAEE LIRDEDSPDF EFIVYDSWKI TGRTAENTFN KTHTFHFLLG SIYGECPVPK PRVDRPRKVP VIQEERAMPA QLRRMEESHQ EATEKEVERI LGLLQTYFRE DPDTPMSFFD FVVDPHSFPR TVENIFHVSF IIRDGFARIR LDQDRLPVIE PVSINEENEG FEHNTQVRNQ GIIALSYRDW EEIVKTFEIS EPVITPSQRQ QKPSA
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Molecular Weight
44.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NSMCE4A is a member of the SMC (Structural Maintenance of Chromosomes) complex, which plays a crucial role in maintaining genomic integrity and cell division. Recent studies have highlighted its involvement in the DNA damage response and repair mechanisms, as well as its potential role in various cancers. Understanding the structure and function of NSMCE4A is vital for elucidating its biological significance and potential as a therapeutic target. Research into NSMCE4A has gained traction due to its unique properties and implications in chromosome organization and stability. The protein is implicated in the regulation of essential cellular processes, such as homologous recombination and sister chromatid cohesion. As the field of molecular biology progresses, the characterization of NSMCE4A and its interactions with other proteins could offer insights into novel pathways that are disrupted in cancer and other diseases. Furthermore, recombinant NSMCE4A proteins are being utilized in biochemical assays to dissect their function, laying the groundwork for targeted drug development. Overall, the study of NSMCE4A represents a significant frontier in our understanding of chromosomal dynamics and its ramifications for human health.
