Analytical Data
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Gene name
UBA6
- Application
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Alternative Names
UBA6；MOP4；UBE1L2；Ubiquitin-like modifier-activating enzyme 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0AVT1-3
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Expression Region
1-389aa
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AA Sequence
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYV LGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWD LGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSF LDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFG DEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLETGQFLTFREI NGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFE SLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQD SEELLKLATSISETLEEKVTIEIYGCPNICLLIHKCSVY
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Molecular Weight
68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBA6 (ubiquitin-like modifier activating enzyme 6) is a crucial protein involved in the ubiquitin-proteasome system, which regulates various cellular processes through protein degradation and modification. Emerging studies indicate that UBA6 plays a vital role in mediating the conjugation of ubiquitin-like modifiers to target proteins, thereby influencing their stability and function. The protein has garnered attention for its implications in various physiological and pathological contexts, including cancer, neurodegenerative diseases, and immune responses. Research on UBA6 has provided insights into its enzymatic activity, which is essential for the activation of ubiquitin-like proteins, such as UFM1. The dysregulation of UBA6 expression or function is linked to various diseases, suggesting that it may serve as a potential therapeutic target. Recent advancements in structural biology have enhanced our understanding of UBA6’s mechanism of action and its interactions with substrate proteins, paving the way for innovative strategies in drug development. Furthermore, studies have highlighted the significance of UBA6 in cellular stress responses and its potential role in regulating autophagy and apoptosis. Given its pivotal function in maintaining cellular homeostasis, ongoing research aims to elucidate the broader implications of UBA6 in health and disease, ultimately contributing to the establishment of novel biomolecular therapies.
