Analytical Data
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基因名
GDE1
- Application
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别名
GDE1；MIR16；Glycerophosphodiester phosphodiesterase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZC3
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表达区间
1-331aa
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氨基酸序列
MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFVLLRVFSFEPV PSCRALQVLKPRDRISAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDI EFTSDGIPVLMHDNTVDRTTDGTGRLCDLTFEQIRKLNPAANHRLRNDFP DEKIPTLREAVAECLNHNLTIFFDVKGHAHKATEALKKMYMEFPQLYNNS VVCSFLPEVIYKMRQTDRDVITALTHRPWSLSHTGDGKPRYDTFWKHFIF VMMDILLDWSMHNILWYLCGISAFLMQKDFVSPAYLKKWSAKGIQVVGWT VNTFDEKSYYESHLGSSYITDSMVEDCEPHF
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分子量
37.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GDE1, or Glycerophosphodiester phosphodiesterase 1, is an enzyme involved in the hydrolysis of glycerophosphodiester substrates, playing a crucial role in phospholipid metabolism and signaling pathways. Its significance extends to various biological processes, including neuronal function, cell signaling, and the regulation of phosphoinositide levels. Recent studies have highlighted that dysregulation of GDE1 can be implicated in several diseases, particularly in the context of neurodegenerative disorders, where altered lipid signaling can exacerbate pathological conditions. The necessity for recombinant GDE1 protein production arises from its potential as a therapeutic target and its utility in understanding the molecular mechanisms underlying its function. The research surrounding GDE1 involves the characterization of its enzymatic activity, substrate specificity, and interaction with other cellular components, providing insights into its role in disease mechanisms. Furthermore, the development of recombinant GDE1 facilitates structure-function studies, aiding in the design of specific inhibitors or modulators that could serve as viable therapeutic agents. Overall, GDE1 represents a significant focus in the field of molecular biology and biochemistry, intertwining basic research with the prospect of clinical applications aimed at treating related disorders.
