Analytical Data
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基因名
DCLK3
- Application
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别名
DCLK3；DCAMKL3；DCDC3C；KIAA1765；Serine/threonine-Protein kinase DCLK3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9C098
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表达区间
1-648aa
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氨基酸序列
MGKEPLTLKS IQVAVEELYP NKARALTLAQ HSRAPSPRLR SRLFSKALKG DHRCGETETP KSCSEVAGCK AAMRHQGKIP EELSLDDRAR TQKKWGRGKW EPEPSSKPPR EATLEERHAR GEKHLGVEIE KTSGEIIRCE KCKRERELQQ SLERERLSLG TSELDMGKGP MYDVEKLVRT RSCRRSPEAN PASGEEGWKG DSHRSSPRNP TQELRRPSKS MDKKEDRGPE DQESHAQGAA KAKKDLVEVL PVTEEGLREV KKDTRPMSRS KHGGWLLREH QAGFEKLRRT RGEEKEAEKE KKPCMSGGRR MTLRDDQPAK LEKEPKTRPE ENKPERPSGR KPRPMGIIAA NVEKHYETGR VIGDGNFAVV KECRHRETRQ AYAMKIIDKS RLKGKEDMVD SEILIIQSLS HPNIVKLHEV YETDMEIYLI LEYVQGGDLF DAIIESVKFP EPDAALMIMD LCKALVHMHD KSIVHRDLKP ENLLVQRNED KSTTLKLADF GLAKHVVRPI FTVCGTPTYV APEILSEKGY GLEVDMWAAG VILYILLCGF PPFRSPERDQ DELFNIIQLG HFEFLPPYWD NISDAAKDLV SRLLVVDPKK RYTAHQVLQH PWIETAGKTN TVKRQKQVSP SSEGHFRSQH KRVVEQVS
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分子量
73.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DCLK3 (Doublecortin-Like Kinase 3) is a member of the doublecortin family, which is implicated in neuronal development and function. Recent studies have suggested that DCLK3 plays a crucial role in neurogenesis and synaptic plasticity, making it a potential target for understanding neurodevelopmental disorders and neurodegenerative diseases. Research has indicated that DCLK3 may be involved in the regulation of microtubule dynamics, critical for neuronal structure and trafficking of cellular components. Additionally, its expression patterns have been associated with various neurological conditions, suggesting that DCLK3 could serve as a biomarker or therapeutic target in these diseases. However, the precise molecular mechanisms underlying DCLK3's function and its potential role in brain pathology remain poorly understood. The recombinant expression of DCLK3 protein is essential for elucidating its functional properties and interactions at a molecular level, providing insights into its role in cellular signaling pathways and potential involvement in disease mechanisms. Understanding DCLK3's structure and function could facilitate the development of novel therapeutic strategies aimed at modulating its activity in diseases characterized by synaptic dysfunction and impaired neurodevelopment.
