Analytical Data
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基因名
PTPLB
- Application
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别名
PTPLB；PTPLB；Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6Y1H2
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表达区间
2-254aa
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氨基酸序列
AAVAATAAAKGNGGGGGRAGAGDASGTRKKKGPGPLATAYLVIYNVVMTAGWLVIAVGLV RAYLAKGSYHSLYYSIEKPLKFFQTGALLEILHCAIGIVPSSVVLTSFQVMSRVFLIWAV THSVKEVQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYLIKWARYTLFIVLYPMGVS GELLTIYAALPFVRQAGLYSISLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHMIHQRR KILSHTEEHKKFE
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分子量
28.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on the PTPLB (Protein Tyrosine Phosphatase-Like B) restructured protein emerges from the growing interest in understanding the role of protein tyrosine phosphatases (PTPs) in cellular signaling and regulation. PTPs are crucial enzymes that remove phosphate groups from tyrosine residues on proteins, thereby influencing various biological processes such as cell growth, differentiation, and metabolism. Dysregulation of PTP activity has been implicated in several diseases, including cancer and diabetes. PTPLB, specifically, is a member of the PTP family that has garnered attention for its potential involvement in modulating immune responses and neurodegenerative diseases. Recent studies suggest that manipulating PTPLB activity could offer novel therapeutic avenues for conditions characterized by hyperactive or dysregulated signaling pathways. By restructuring PTPLB through techniques such as gene editing and protein engineering, researchers aim to enhance our understanding of its functional mechanisms and explore its potential as a target for drug discovery. This research not only deepens the comprehension of PTP roles in health and disease but also paves the way for innovative therapeutic strategies that leverage the precise modulation of phosphatase activities in various pathological contexts.
