Analytical Data
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Gene name
NEUROD4
- Application
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Alternative Names
NEUROD4; ATH3; ATOH3; BHLHA4; Neurogenic differentiation factor 4; NeuroD4; Class A basic helix-loop-helix protein 4; bHLHa4; Protein atonal homolog 3; ATH-3; Atoh3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HD90
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Expression Region
1-331 aa
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AA Sequence
MSKTFVKSKE MGELVNTPSW MDKGLGSQNE VKEEESRPGT YGMLSSLTEE HDSIEEEEEE EEDGEKPKRR GPKKKKMTKA RLERFRARRV KANARERTRM HGLNDALDNL RRVMPCYSKT QKLSKIETLR LARNYIWALS EVLETGQTPE GKGFVEMLCK GLSQPTSNLV AGCLQLGPQS VLLEKHEDKS PICDSAISVH NFNYQSPGLP SPPYGHMETH LLHLKPQVFK SLGESSFGSH LPDCSTPPYE GPLTPPLSIS GNFSLKQDGS PDLEKSYSFM PHYPSSSLSS GHVHSTPFQA GTPRYDVPID MSYDSYPHHG IGTQLNTVFT E
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Molecular Weight
37.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NEUROD4, a member of the NEUROD family of basic helix-loop-helix transcription factors, plays a crucial role in the development and differentiation of neural lineages, particularly in the formation of neurons and insulin-producing beta cells in the pancreas. Its expression is tightly regulated during embryonic development, and it is implicated in neurogenesis, tumorgenesis, and cellular reprogramming. The study of NEUROD4 has gained prominence due to its potential therapeutic applications, particularly in regenerative medicine and diabetes treatment. Understanding the mechanisms by which NEUROD4 influences cell fate and its interactions with other signaling pathways can provide insights for developing novel strategies for neurodegenerative diseases and metabolic disorders. Researchers have increasingly focused on the production and characterization of recombinant NEUROD4 proteins to elucidate its structure-function relationships and to explore its capabilities in promoting neuronal differentiation in various stem cell models. This recombinant approach enables detailed investigations into NEUROD4’s functional domains and its role in transcriptional regulation, thereby paving the way for future biotechnological applications in cell therapy and biotechnology. The ongoing research aims to harness the potential of NEUROD4 in therapeutic contexts, emphasizing its significance in both fundamental biology and clinical applications.
