Analytical Data
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Gene name
IHPK2
- Application
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Alternative Names
IHPK2；IHPK2；Inositol hexakisphosphate kinase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UHH9
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Expression Region
1-426aa
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AA Sequence
MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQ FYETLPAEMRKFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVD NSDCEPKSKLLRWTTNKKHHVLETEKTPKDWVRQHRKEEKMKSHKLEEEF EWLKKSEVLYYTVEKKGNISSQLKHYNPWSMKCHQQQLQRMKENAKHRNQ YKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSA VIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLR RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAE DLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHE GQDAGYIFGLQSLIDIVTEISEESGEHHHHHHGGGLNDIFEAQKIEWHE
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Molecular Weight
52 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IHPK2 (Inositol hexakisphosphate kinase 2) is a member of the inositol phosphates signaling pathway, which plays a crucial role in various cellular processes including cell growth, differentiation, and apoptosis. Increased understanding of IHPK2 has emerged due to its potential involvement in several diseases, particularly cancers and metabolic disorders. Research has indicated that IHPK2 functions as a regulatory enzyme converting inositol hexakisphosphate (InsP6) into inositol pyrophosphates, which are important signaling molecules within the cell. This pathway’s dysregulation has been linked to altered cellular responses and pathological conditions. Given its pivotal role in cell signaling, IHPK2 is being investigated for its potential as a therapeutic target. Moreover, the study of recombinant IHPK2 proteins facilitates the understanding of their biochemical properties and interactions. Characterizing these proteins can provide insights into their enzymatic functions and regulatory mechanisms, which is essential for developing novel therapeutic approaches. As the biochemical pathways involving inositol phosphates continue to be elucidated, IHPK2’s role could become increasingly significant in drug development and disease management strategies.
