Analytical Data
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Gene name
NEUROG1
- Application
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Alternative Names
AKA; Ath4c; bHLHa6; Class A basic helix-loop-helix protein 6; Helix loop helix protein mATH 4C; MATH4C; NeuroD3; Neurog 1; Neurog1; Neurogenic basic helix loop helix protein; Neurogenic basic-helix-loop-helix protein; Neurogenic differentiation 3; Neurogenic differentiation factor 3; Neurogenin-1; Neurogenin1; Ngn; NGN-1; Ngn1; NGN1_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92886
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Expression Region
1-237 aa
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AA Sequence
MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH
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Molecular Weight
25.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NEUROG1, a member of the basic helix-loop-helix (bHLH) transcription factor family, plays a pivotal role in neurogenesis and the differentiation of neural progenitor cells. It has garnered significant attention in recent years due to its crucial function in promoting the development of the central nervous system during embryogenesis. Dysregulation of NEUROG1 expression has been implicated in various neurodevelopmental disorders and has potential links to neurodegenerative conditions, making it a candidate for therapeutic interventions. Research into the recombinant production of NEUROG1 protein aims to shed light on its molecular mechanisms and facilitate the understanding of its interactions with downstream targets involved in neural development. Furthermore, the availability of this protein can enhance studies on its structural properties and facilitate high-throughput screening for small molecules that might modulate NEUROG1 activity. Advances in recombinant DNA technology, coupled with improved expression systems, have made it feasible to produce NEUROG1 in sufficient quantities for biochemical and biophysical characterization. This research is expected to provide insight into how NEUROG1 regulates gene expression during neural cell fate determination and may unveil novel therapeutic strategies for neurodevelopmental and neurodegenerative diseases. The comprehensive analysis of the functional role of NEUROG1 can, therefore, contribute to a better understanding of neural developmental pathways and the potential for regenerative therapies targeting the nervous system.
