Analytical Data
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Gene name
RND1
- Application
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Alternative Names
RND1;RHO6;Rho-related GTP-binding Protein Rho6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92730
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Expression Region
1-200aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH SPYYDNVRPL CYSDSDAVLL CFDISRPETV DSALKKWRTE ILDYCPSTRV LLIGCKTDLR TDLSTLMELS HQKQAPISYE QGCAIAKQLG MKERRAPQPV VARCKLVLVG DVQCGKTAML QVLAKDCYPE TYVPTVFENY TACLETEEQR VELSLWDTSG AEIYLEGSAF TSEKSIHSIF RTASMLCLNK PSPLPQKSPV
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Molecular Weight
25 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RND1 (Rho family GTPase 1) is a member of the Rho GTPase family, which plays a crucial role in various cellular processes, including cytoskeletal dynamics, cell migration, and proliferation. Research into RND1 has garnered interest due to its unique regulatory functions and potential implications in cancer biology and developmental signaling pathways. Unlike other Rho GTPases that are predominantly involved in cell signaling mediated by GTP-bound active forms, RND1 is known to be constitutively active, leading to distinct cellular effects. It has been implicated in the inhibition of neuronal differentiation and the promotion of cell survival, suggesting a multifaceted role in maintaining cellular homeostasis. Moreover, aberrant RND1 expression has been linked to several pathologies, including tumorigenesis and neurodegenerative disorders. Consequently, the study of RND1 recombinant proteins is vital for elucidating its mechanistic roles and interactions at the molecular level. By producing and characterizing recombinant RND1 proteins, researchers aim to investigate its biochemical properties, binding partners, and downstream signaling pathways. This knowledge could not only enhance our understanding of RND1's functional roles in cell biology but may also reveal novel therapeutic targets for related diseases. Thus, the exploration of RND1 as a recombinant protein serves to bridge gaps in our comprehension of its contributions to both normal physiology and disease states, paving the way for future advancements in targeted therapies.
