Cat: PA1000-2694

Recombinant Human RDBP Protein,His

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Analytical Data

  • Gene name

    RDBP

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    NELFE;RD;RDBP;Negative elongation factor E

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    P18615

  • Expression Region

    1-380aa

  • AA Sequence

    MLVIPPGLSE EEEALQKKFN KLKKKKKALL ALKKQSSSST TSQGGVKRSL SEQPVMDTAT ATEQAKQLVK SGAISAIKAE TKNSGFKRSR TLEGKLKDPE KGPVPTFQPF QRSISADDDL QESSRRPQRK SLYESFVSSS DRLRELGPDG EEAEGPGAGD GPPRSFDWGY EERSGAHSSA SPPRSRSRDR SHERNRDRDR DRERDRDRDR DRDRERDRDR DRDRDRDRER DRDRERDRDR DREGPFRRSD SFPERRAPRK GNTLYVYGED MTPTLLRGAF SPFGNIIDLS MDPPRNCAFV TYEKMESADQ AVAELNGTQV ESVQLKVNIA RKQPMLDAAT GKSVWGSLAV QNSPKGCHRD KRTQIVYSDD VYKENLVDGF

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

RDBP (Retinoic acid-dependent nuclear receptor binding protein) is a crucial protein that plays a significant role in various biological processes, including gene regulation, cellular differentiation, and embryonic development. Its function is closely associated with retinoic acid signaling, which is essential for normal vertebrate development and maintains homeostasis in adult tissues. Recent studies have highlighted the importance of RDBP in influencing the expression of genes that are vital for cellular responses to retinoic acid, making it a key player in developmental biology and molecular medicine. Additionally, aberrations in RDBP expression or function have been linked to various diseases, including cancer. Understanding the structure and function of RDBP through recombinant protein studies can provide valuable insights into its mechanisms of action and potential therapeutic applications. Researchers have been focusing on the expression, purification, and characterization of RDBP to elucidate its interactions with retinoic acid and other nuclear receptors. This research aims to uncover the molecular pathways mediated by RDBP, paving the way for innovative treatments targeting retinoic acid signaling pathways in disease contexts, thereby establishing RDBP as a significant target for drug discovery and development in the field of regenerative medicine and oncology.

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