Analytical Data
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基因名
NBEA
- Application
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别名
BCL8B; FLJ10197; KIAA1544; Lysosomal trafficking regulator 2; Lysosomal-trafficking regulator 2; LYST2; NBEA; NBEA_HUMAN; Neurobeachin; Protein BCL8B; Protein neurobeachin; RP11-270C18.1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NFP9
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表达区间
1133-1220 aa
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氨基酸序列
ADEKEDLPNSSTSFLFDKIPKQEEKLLPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHTTSDGMSSI
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分子量
35.42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NBEA (neurobeachin) is a key protein involved in neuronal development and synaptic function, playing a crucial role in intracellular signaling and the organization of the cytoskeleton. Its significance has been underscored by studies linking NBEA mutations to neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders. Research into NBEA recombinant proteins aims to elucidate its structural and functional properties, providing insights into its role in neuronal connectivity and signaling pathways. The capacity to produce NBEA as a recombinant protein facilitates the exploration of its interaction with other cellular components and the understanding of its mechanisms at the molecular level. Furthermore, this research holds potential for therapeutic applications, as targeting the pathways influenced by NBEA could offer new strategies for treating related neurological conditions. By employing advanced biotechnological methods, scientists aim to address the challenges posed by NBEA's complex structure, ultimately advancing our understanding of its contributions to brain function and its relevance in disease.
