Analytical Data
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基因名
RCN2
- Application
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别名
RCN2;ERC55;Reticulocalbin-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14257
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表达区间
26-317aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMEELHYPLGERRSDYDREALLGV QEDVD EYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHY AMQ EAKQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESF R KLHLKDKKRFEKANQDSGPGLSLEEFIAFEHPEEVDYMTEFVIQEALEE HDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGR L DPQELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDL FLTSEATDYGRQLHDDYFYHDEL
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RCN2, or Recoverin-like Calcium Binding Protein 2, is a member of the recoverin family, which plays a significant role in calcium signaling and homeostasis within cells. The protein is characterized by its ability to bind calcium ions, thus influencing various cellular processes such as synaptic transmission, gene expression, and cell survival. Its involvement in neuronal functioning makes RCN2 particularly relevant in the context of neurodegenerative diseases and synaptic disorders. Recent studies have shown that RCN2 may have implications in modulating calcium-dependent pathways, which are critical for maintaining neuronal health and preventing excitotoxicity. Given its potential as a biomarker or therapeutic target, the recombinant expression of RCN2 in various model systems has been pursued to further understand its structure-function relationship and cellular interactions. By generating RCN2 as a recombinant protein, researchers aim to investigate its biochemical properties, explore its role in calcium-binding dynamics, and assess its impact on neuronal health and plasticity. This research could pave the way for innovative strategies in treating neurological conditions associated with calcium dysregulation, underscoring the importance of RCN2 in both basic and applied biomedical sciences.
