Analytical Data
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Gene name
NAV2
- Application
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Alternative Names
Helicase APC down-regulated 1;Pore membrane and/or filament-interacting-like protein 2;Retinoic acid inducible in neuroblastoma 1;Steerin-2;Unc-53 homolog 2;unc53H2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IVL1
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Expression Region
950-1100 aa
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AA Sequence
SSSVSSGISDTIDNLSTDDINTSSSISSYANTPASSRKNLDVQTDAEKHSQVERNSLWSGDDVKKSDGGSDSGIKMEPGSKWRRNPSDVSDESDKSTSGKKNPVISQTGSWRRGMTAQVGITMPRTKPSAPAGALKTPGTGKTDDAKVSEK
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Molecular Weight
22.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NAV2 (Neuron Navigator 2) is a member of the Navigator family of proteins, which are implicated in neuronal development and guidance. The study of NAV2 has gained attention due to its potential role in various neurological disorders, including neurodegenerative diseases and developmental abnormalities. NAV2 is believed to function in cytoskeletal dynamics and neuronal morphology, affecting how neurons connect and communicate. Recent investigations have focused on understanding the molecular mechanisms underlying NAV2's influence on axon growth and guidance during neuronal development. Its interactions with microtubules and actin filaments are particularly significant, as they are crucial for maintaining neuronal integrity and function. Moreover, alterations in NAV2 expression or function have been linked to various pathophysiological conditions, prompting researchers to explore its potential as a therapeutic target. The characterization of NAV2 as a recombinant protein in laboratory settings provides a valuable tool for elucidating its biochemical properties and interactions. Understanding NAV2's structure-function relationship can pave the way for innovative approaches in treating neurological disorders, highlighting its importance in both basic neuroscience and clinical research.
