Analytical Data
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基因名
RARα
- Application
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别名
;
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P54136
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表达区间
1-660aa
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氨基酸序列
MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLK LKYRLNILRKSLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPL LVTPSQQAKFGDYQCNSAMGISQMLKTKEQKVNPREIAENITKHLPDNEC IEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPALGENKKVIVDFSS PNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIA HLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGK NPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFE DRGFVQVDDGRKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEK ADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKK KFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAY GCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANI DEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDY IYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFD ILGIKPVQRM
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分子量
99 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RARα (Retinoic Acid Receptor Alpha) is a nuclear receptor that plays a critical role in the regulation of gene expression in response to retinoic acid, a metabolite of vitamin A. It is implicated in various physiological processes including embryonic development, differentiation, and cellular proliferation. Additionally, RARα is a key player in several pathological conditions, most notably in acute promyelocytic leukemia (APL), where a fusion protein with promyelocytic leukemia (PML) protein disrupts normal RARα function, leading to oncogenesis. The study of RARα recombinant proteins has gained significant attention as researchers aim to understand the molecular mechanisms underlying its function and its interactions with other proteins. These recombinant proteins are invaluable for dissecting the signaling pathways that govern cell behavior and for developing therapeutic strategies. By characterizing RARα at the molecular level, scientists hope to reveal potential targets for drug design, especially for conditions associated with retinoid signaling dysregulation. Furthermore, experiments involving RARα recombinant proteins can provide insights into ligand binding dynamics and transcriptional regulation processes. As a result, RARα remains a prominent focus in cancer research and developmental biology, with ongoing studies aimed at fully elucidating its roles and therapeutic potential.
