Analytical Data
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Gene name
NACA2
- Application
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Alternative Names
NACA2; NACAL; Nascent polypeptide-associated complex subunit alpha-2; Alpha-NAC-like; Hom s 2.01; Nascent polypeptide-associated complex subunit alpha-like; NAC-alpha-like
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H009
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Expression Region
1-215 aa
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AA Sequence
MPGEATETVP ATEQELPQSQ AETGSGTASD SGESVPGIEE QDSTQTTTQK AWLVAAAEID EEPVGKAKQS RSEKRARKAM SKLGLLQVTG VTRVTIWKSK NILFVITKLD VYKSPASDAY IVFGEAKIQD LSQQAQLAAA EKFRVQGEAV GNIQENTQTP TVQEESEEEE VDETGVEVKD VKLVMSQANV SRAKAVRALK NNSNDIVNAI MELTV
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Molecular Weight
23.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NACA2, or Nascent Polypeptide-Associated Complex Subunit 2, is a protein that plays a crucial role in the early stages of protein synthesis and folding. The study of NACA2 is significant due to its involvement in the chaperone complex, which assists nascent polypeptides in avoiding misfolding and aggregation during translation. Research has shown that NACA2 interacts with ribosomes and nascent chains, facilitating the proper folding of newly synthesized proteins. This function is particularly important in the context of various diseases, including neurodegenerative disorders, where protein misfolding and aggregation are prevalent. Understanding NACA2's mechanism could provide insights into the therapeutic strategies for these conditions. Moreover, NACA2 is also implicated in regulating the immune response and cellular stress responses, further emphasizing its biological significance. Given the central role of protein homeostasis in cellular function, investigating NACA2’s structure, function, and interactions can elucidate its potential as a target for drug development and therapeutic intervention. This makes the study of NACA2 a promising avenue for understanding both fundamental biological processes and the molecular underpinnings of diseases associated with protein misfolding.
