Analytical Data
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基因名
MTMR3
- Application
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别名
FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; ; _HUMAN; Myotubularin-related protein 3; Zinc finger FYVE domain-containing protein 10
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13615
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表达区间
579-674 aa
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氨基酸序列
CPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPG
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分子量
36.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MTMR3 (Myotubularin-related protein 3) is a member of the myotubularin family of lipid phosphatases, which are involved in cellular processes such as phosphoinositide metabolism and endosomal trafficking. Research on MTMR3 has garnered attention due to its association with various cellular functions that are crucial for muscle development and function. Mutations in the MTMR3 gene have been linked to Charcot-Marie-Tooth disease, a hereditary neuropathy that affects peripheral nerves, highlighting the importance of this protein in neurological health. Additionally, MTMR3 is speculated to play a role in lipid homeostasis and autophagy, making it a potential target for understanding and treating metabolic and neurodegenerative disorders. The recombinant expression of MTMR3 protein allows for detailed biochemical assays to elucidate its enzymatic activity, substrate specificity, and interactions with other cellular components. Exploring the structure-function relationship of MTMR3 through recombinant technology can provide insights into the pathogenic mechanisms underlying related diseases and may open avenues for novel therapeutic strategies aimed at mitigating the effects of MTMR3 deficiencies. Therefore, the study of MTMR3 not only contributes to basic biological knowledge but also has promising implications for clinical research in neuromuscular and metabolic disorders.
