Analytical Data
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Gene name
MTERFD1
- Application
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Alternative Names
CGI 12; mitochondrial; Mitochondrial transcription termination factor 3; MTER1_HUMAN; MTERF domain containing 1 ; mTERF domain containing protein 1 mitochondrial; mTERF domain-containing protein 1; mTERF3; Mterfd1; Transcription termination factor 3. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96E29
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Expression Region
69-417 aa
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AA Sequence
SS QSTSSSSQEN NSAQSSLLPS MNEQSQKTQN ISSFDSELFL EELDELPPLS PMQPISEEEA IQIIADPPLP PASFTLRDYV DHSETLQKLV LLGVDLSKIE KHPEAANLLL RLDFEKDIKQ MLLFLKDVGI EDNQLGAFLT KNHAIFSEDL ENLKTRVAYL HSKNFSKADV AQMVRKAPFL LNFSVERLDN RLGFFQKELE LSVKKTRDLV VRLPRLLTGS LEPVKENMKV YRLELGFKHN EIQHMITRIP KMLTANKMKL TETFDFVHNV MSIPHHIIVK FPQVFNTRLF KVKERHLFLT YLGRAQYDPA KPNYISLDKL VSIPDEIFCE EIAKASVQDF EKFLKTL
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Molecular Weight
47.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MTERFD1 (Mitogen-Activated Protein/ERK Kinase Kinase 1-Targeting Protein 1) has emerged as an important player in cellular signaling and regulation of cellular processes, particularly in relation to the mitochondrial function and energy metabolism. Its role has garnered attention in cancer research, where altered mitochondrial dynamics and energy production are critical for tumor growth and survival. MTERFD1 is believed to interact with several key signaling pathways, including those mediated by the ERK/MAPK cascade, which is instrumental in proliferation and differentiation. Furthermore, the protein has been implicated in oxidative stress responses, highlighting its potential as a mediator between metabolic alterations and cellular stress. Understanding MTERFD1's molecular mechanisms through the study of its recombinant protein could provide valuable insights into its functions and interactions, paving the way for new therapeutic strategies targeting metabolic disorders and cancer. As research progresses, the characterization of MTERFD1 through recombinant protein studies has the potential to reveal its structure-function relationships, elucidate its role in mitochondrial dynamics, and offer avenues for innovative treatments in conditions where mitochondrial dysfunction is a hallmark. This study not only aims to delineate the biological significance of MTERFD1 but also to contribute to the growing body of knowledge regarding mitochondrial regulation in health and disease.
