Analytical Data
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Gene name
MSL1
- Application
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Alternative Names
hMSL1; male specific lethal 1; male specific lethal 1 homolog 1; male specific lethal 1 homolog; male specific lethal 1 like 1; Male-specific lethal 1 homolog; Male-specific lethal 1-like 1; Male-specific lethal-1 homolog 1; MSL 1; MSL-1; Msl1; MSL1 like 1; MSL1-like 1; MSL1_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q68DK7
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Expression Region
1-614 aa
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AA Sequence
MTMRSAVFKA AAAPAGGNPE QRLDYERAAA LGGPEDEPGA AEAHFLPRHR KLKEPGPPLA SSQGGSPAPS PAGCGGKGRG LLLPAGAAPG QQEESWGGSV PLPCPPPATK QAGIGGEPAA AGAGCSPRPK YQAVLPIQTG SLVAAAKEPT PWAGDKGGAA SPAATASDPA GPPPLPLPGP PPLAPTATAG TLAASEGRWK SMRKSPLGGG GGSGASSQAA CLKQILLLQL DLIEQQQQQL QAKEKEIEEL KSERDTLLAR IERMERRMQL VKKDNEKERH KLFQGYETEE REETELSEKI KLECQPELSE TSQTLPPKPF SCGRSGKGHK RKSPFGSTER KTPVKKLAPE FSKVKTKTPK HSPIKEEPCG SLSETVCKRE LRSQETPEKP RSSVDTPPRL STPQKGPSTH PKEKAFSSEI EDLPYLSTTE MYLCRWHQPP PSPLPLRESS PKKEETVARC LMPSSVAGET SVLAVPSWRD HSVEPLRDPN PSDLLENLDD SVFSKRHAKL ELDEKRRKRW DIQRIREQRI LQRLQLRMYK KKGIQESEPE VTSFFPEPDD VESLMITPFL PVVAFGRPLP KLTPQNFELP WLDERSRCRL EIQKKQTPHR TCRK
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Molecular Weight
67.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MSL1, or Male-Specific Lethal 1, is a key component of the dosage compensation complex in Drosophila, responsible for equalizing gene expression between males (XY) and females (XX). This complex ensures that males, which possess a single X chromosome, can express genes from that chromosome at levels comparable to those in females, thus preventing underexpression of X-linked genes in males. The study of MSL1 is crucial for understanding the molecular mechanisms of dosage compensation, a fundamental genetic process across many species. Researchers have shown that MSL1 binds to specific chromatin sites on the X chromosome, facilitating the recruitment of other proteins involved in this complex. Additionally, the investigation of MSL1 in Drosophila has broader implications for understanding sex-biased diseases and the evolutionary mechanisms behind sex chromosome evolution. Current research often focuses on the structural and functional characterization of MSL1, its interactions with RNA and other proteins, and its role in chromatin remodeling. Understanding how MSL1 operates at the molecular level can reveal insights into gene regulation and has potential applications in therapeutic strategies for sex-linked disorders. As such, MSL1 serves as a fascinating model for exploring both the fundamentals of genetic regulation and the intricate balance of gene expression required for proper organismal development.
