Analytical Data
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Gene name
PTPN7
- Application
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Alternative Names
PTPN7;Tyrosine-Protein phosphatase non-receptor type 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5SXQ0
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Expression Region
1-360aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMVQAHG GRSRAQPLTL SLGAAMTQPP PEKTPAKKHV RLQERRGSNV ALMLDVRSLG AVEPICSVNT PREVTLHFLR TAGHPLTRWA LQRQPPSPKQ LEEEFLKIPS NFVSPEDLDI PGHASKDRYK TILPNPQSRV CLGRAQSQED GDYINANYIR GYDGKEKVYI ATQGPMPNTV SDFWEMVWQE EVSLIVMLTQ LREGKEKCVH YWPTEEETYG PFQIRIQDMK ECPEYTVRQL TIQYQEERRS VKHILFSAWP DHQTPESAGP LLRLVAEVEE SPETAAHPGP IVVHCSAGIG RTGCFIATRI GCQQLKARGE VDILGIVCQL RLDRGGMIQT AEQYQFLHHT LALYAGQLPE EPSP
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Molecular Weight
43 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPN7, also known as Protein Tyrosine Phosphatase, Non-Receptor Type 7, is a member of the protein tyrosine phosphatase family, which plays a critical role in various cellular processes by regulating phosphorylation states of tyrosine residues in proteins. Research into PTPN7 has gained momentum due to its involvement in several key signaling pathways that influence immune responses, cell proliferation, and differentiation. The enzyme is known to interact with various substrates, including molecules involved in signal transduction, indicating its potential role in modulating cellular outcomes. Studies suggest that PTPN7 may be implicated in autoimmune diseases and cancers, making it a target of therapeutic interest. Moreover, the generation of recombinant PTPN7 protein has become essential for detailed biochemical characterization and high-throughput screening studies aimed at understanding its function and mechanism of action. Through such studies, researchers aim to elucidate the precise role of PTPN7 in cellular signaling and its potential as a biomarker or therapeutic target. Additionally, insights gained from recombinant PTPN7 can contribute to developing strategies for modulating its activity in disease contexts, ultimately paving the way for new treatment options in conditions characterized by dysregulated phosphatase activity.
