Analytical Data
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基因名
MS4A4A
- Application
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别名
CD20 antigen-like 1;Four-span transmembrane protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96JQ5
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表达区间
1-239 aa
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氨基酸序列
MHQTYSRHCRPEESTFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV
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分子量
26.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MS4A4A, a member of the membrane-spanning 4-domains subfamily A (MS4A) family, has garnered attention in recent years due to its potential role in various biological processes and diseases. This protein is predominantly expressed in immune cells, particularly B cells, and is implicated in regulating intracellular signaling pathways that influence cell activation, development, and differentiation. Research has indicated that MS4A4A may be involved in the pathogenesis of several conditions, including autoimmune diseases and certain cancers. Genetic studies have linked variations in the MS4A4A gene to susceptibility to diseases such as multiple sclerosis and Alzheimer’s, underscoring its importance in immune system functionality and neuroinflammation. Given its significant role in immune modulation, researchers are increasingly interested in generating recombinant MS4A4A proteins to better understand their structure-function relationships and interactions with other signaling molecules. By employing techniques such as protein expression systems and purification methods, scientists aim to elucidate the molecular mechanisms underlying MS4A4A's actions in health and disease. This research not only provides insights into MS4A4A’s biological relevance but also holds the potential for the development of therapeutic interventions targeting MS4A4A for treating immune-related disorders.
