Analytical Data
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Gene name
MS4A4A
- Application
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Alternative Names
CD20 antigen-like 1;Four-span transmembrane protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96JQ5
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Expression Region
1-239 aa
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AA Sequence
MHQTYSRHCRPEESTFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV
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Molecular Weight
26.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MS4A4A, a member of the membrane-spanning 4-domains subfamily A (MS4A) family, has garnered attention in recent years due to its potential role in various biological processes and diseases. This protein is predominantly expressed in immune cells, particularly B cells, and is implicated in regulating intracellular signaling pathways that influence cell activation, development, and differentiation. Research has indicated that MS4A4A may be involved in the pathogenesis of several conditions, including autoimmune diseases and certain cancers. Genetic studies have linked variations in the MS4A4A gene to susceptibility to diseases such as multiple sclerosis and Alzheimer’s, underscoring its importance in immune system functionality and neuroinflammation. Given its significant role in immune modulation, researchers are increasingly interested in generating recombinant MS4A4A proteins to better understand their structure-function relationships and interactions with other signaling molecules. By employing techniques such as protein expression systems and purification methods, scientists aim to elucidate the molecular mechanisms underlying MS4A4A's actions in health and disease. This research not only provides insights into MS4A4A’s biological relevance but also holds the potential for the development of therapeutic interventions targeting MS4A4A for treating immune-related disorders.
