Analytical Data
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Gene name
PSMD5
- Application
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Alternative Names
PSMD5;KIAA0072;26S proteasome non-ATPase regulatory subunit 5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16401
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Expression Region
1-504aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSEFMAAQALALLREVARLEAPLEELRAL HSVLQAVPLNELRQQAAELRLGPLFSLLNENHREKTTLCVSILERLLQAM EPVHVARNLRVDLQRGLIHPDDSVKILTLSQIGRIVENSDAVTEILNNAE LLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKSVM KTNDIVRYRVYELIIEISSVSPESLNYCTTSGLVTQLLRELTGEDVLVRA TCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVK FFGNLAVMDSPQQICERYPIFVEKVFEMIESQDPTMIGVAVDTVGILGSN VEGKQVLQKTGTRFERLLMRIGHQSKNAPVELKIRCLDAISSLLYLPPEQ QTDDLLRMTESWFSSLSRDPLELFRGISSQPFPELHCAALKVFTAIANQP WAQKLMFNSPGFVEYVVDRSVEHDKASKDAKYELVKALANSKTIAEIFGN PNYLRLRTYLSEGPYYVKPVSTTAVEGAE
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Molecular Weight
59 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMD5 is a pivotal component of the 26S proteasome, a multi-subunit protease complex responsible for protein degradation in eukaryotic cells. The proteasome plays a crucial role in regulating various cellular processes, including the cell cycle, signal transduction, and apoptosis, by ensuring the controlled degradation of misfolded, damaged, or unneeded proteins. PSMD5, specifically, functions as a non-ATPase regulatory subunit and is involved in the recognition and translocation of ubiquitinated substrates into the proteolytic core of the proteasome. Emerging research highlights the importance of PSMD5 in various diseases, particularly cancer, where its expression levels can influence tumor progression and therapeutic responses. Additionally, altered PSMD5 activity has been implicated in neurodegenerative disorders, underscoring its significance in maintaining cellular homeostasis. Recent studies also suggest potential therapeutic strategies targeting the PSMD5 pathway, aiming to enhance proteasomal activity or inhibit specific interactions critical for disease progression. Understanding the structural and functional aspects of PSMD5, along with its regulatory mechanisms, can pave the way for novel interventions in diseases associated with proteasome dysfunction. Thus, the study of PSMD5 not only provides insights into fundamental cellular processes but also opens avenues for developing targeted therapies in oncology and other diseases characterized by protein homeostasis disruptions.
