Analytical Data
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Gene name
PSMA8
- Application
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Alternative Names
PSMA8;PSMA7L;Proteasome subunit alpha-type 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TAA3
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Expression Region
1-250aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT VRKICALDDH VCMAFAGLTA DARVVINRAR VECQSHKLTV EDPVTVEYIT RFIATLKQKY TQSNGRRPFG ISALIVGFDD DGISRLYQTD PSGTYHAWKA NAIGRSAKTV REFLEKNYTE DAIASDSEAI KLAIKALLEV VQSGGKNIEL AIIRRNQPLK MFSAKEVELY VTEIEKEKEE AEKKKSKKSV
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Molecular Weight
30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMA8, also known as proteasome subunit alpha type-8, is a key component of the 26S proteasome, a multiprotein complex essential for degrading ubiquitinated proteins and regulating various cellular processes such as the cell cycle, DNA repair, and immune response. Dysregulation of the proteasome pathway is linked to various diseases, including cancer and neurodegenerative disorders. Research on PSMA8 has garnered interest due to its role in the proteolytic system and its potential implications in disease mechanisms. Studies have shown that alterations in PSMA8 expression can affect proteasome activity, leading to disruptions in protein homeostasis. Additionally, PSMA8 has been identified as a target for therapeutic intervention, particularly in cancer, where enhancing proteasome activity may improve the efficacy of certain treatments. Understanding the structure, function, and regulatory mechanisms of PSMA8 is crucial for discovering novel strategies for disease intervention. Current research is focused on elucidating the role of PSMA8 in various cellular contexts and exploring its potential as a biomarker or therapeutic target in disease management.
