Analytical Data
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基因名
GPX6
- Application
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别名
GPX6；Glutathione peroxidase 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P59796
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表达区间
20-221aa
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氨基酸序列
Q QTLKPQNRKV DCNKGVTGTI YEYGALTLNG EEYIQFKQFA GKHVLFVNVA AYUGLAAQYP ELNALQEELK NFGVIVLAFP CNQFGKQEPG TNSEILLGLK YVCPGSGFVP SFQLFEKGDV NGEKEQKVFT FLKNSCPPTS DLLGSSSQLF WEPMKVHDIR WNFEKFLVGP DGVPVMHWFH QAPVSTVKSD ILEYLKQFNT H
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分子量
24.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPX6, or Glutathione Peroxidase 6, is an important enzyme belonging to the glutathione peroxidase family, which plays a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and lipid hydroperoxides. Research has indicated that GPX6 is primarily expressed in the brain and reproductive tissues, suggesting its potential involvement in neuroprotection and fertility. The enzyme's role in maintaining cellular redox balance has sparked interest in its implications for neurodegenerative diseases, where oxidative damage is a key pathogenic factor. Furthermore, studies have shown that GPX6 may have unique substrate specificity and regulatory mechanisms compared to other isoforms, prompting scientists to investigate its biochemical properties and potential therapeutic applications. Understanding the structure and function of GPX6, including its role in modulation of reactive oxygen species and the cellular response to stress, could lead to innovative strategies for treating conditions linked to oxidative damage, such as Alzheimer's disease and infertility. Thus, the characterization of GPX6 recombinant proteins has gained traction, as it provides a valuable tool for elucidating the enzyme's mechanisms and potential clinical relevance.
