Analytical Data
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Gene name
GPX6
- Application
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Alternative Names
GPX6；Glutathione peroxidase 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P59796
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Expression Region
20-221aa
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AA Sequence
Q QTLKPQNRKV DCNKGVTGTI YEYGALTLNG EEYIQFKQFA GKHVLFVNVA AYUGLAAQYP ELNALQEELK NFGVIVLAFP CNQFGKQEPG TNSEILLGLK YVCPGSGFVP SFQLFEKGDV NGEKEQKVFT FLKNSCPPTS DLLGSSSQLF WEPMKVHDIR WNFEKFLVGP DGVPVMHWFH QAPVSTVKSD ILEYLKQFNT H
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Molecular Weight
24.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GPX6, or Glutathione Peroxidase 6, is an important enzyme belonging to the glutathione peroxidase family, which plays a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and lipid hydroperoxides. Research has indicated that GPX6 is primarily expressed in the brain and reproductive tissues, suggesting its potential involvement in neuroprotection and fertility. The enzyme's role in maintaining cellular redox balance has sparked interest in its implications for neurodegenerative diseases, where oxidative damage is a key pathogenic factor. Furthermore, studies have shown that GPX6 may have unique substrate specificity and regulatory mechanisms compared to other isoforms, prompting scientists to investigate its biochemical properties and potential therapeutic applications. Understanding the structure and function of GPX6, including its role in modulation of reactive oxygen species and the cellular response to stress, could lead to innovative strategies for treating conditions linked to oxidative damage, such as Alzheimer's disease and infertility. Thus, the characterization of GPX6 recombinant proteins has gained traction, as it provides a valuable tool for elucidating the enzyme's mechanisms and potential clinical relevance.
