Analytical Data
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基因名
MRGPRD
- Application
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别名
Beta-alanine receptor;G-protein coupled receptor TGR7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TDS7
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表达区间
1-321 aa
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氨基酸序列
MNQTLNSSGTVESALNYSRGSTVHTAYLVLSSLAMFTCLCGMAGNSMVIWLLGFRMHRNPFCIYILNLAAADLLFLFSMASTLSLETQPLVNTTDKVHELMKRLMYFAYTVGLSLLTAISTQRCLSVLFPIWFKCHRPRHLSAWVCGLLWTLCLLMNGLTSSFCSKFLKFNEDRCFRVDMVQAALIMGVLTPVMTLSSLTLFVWVRRSSQQWRRQPTRLFVVVLASVLVFLICSLPLSIYWFVLYWLSLPPEMQVLCFSLSRLSSSVSSSANPVIYFLVGSRRSHRLPTRSLGTVLQQALREEPELEGGETPTVGTNEMGA
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分子量
42.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MRGPRD protein, a member of the Mas-related G protein-coupled receptor (GPCR) family, has garnered considerable interest in research due to its significant role in pain sensing and itch perception. Identified primarily in sensory neurons, MRGPRD appears to be involved in the modulation of pain signals and is implicated in various inflammatory responses. Its activation can lead to the release of pro-inflammatory mediators, suggesting a crucial function in the pathophysiology of chronic pain and allergic reactions. Recent studies have explored the receptor's signaling mechanisms, revealing potential pathways that could be targeted for therapeutic interventions in pain management and itch relief. Additionally, the reconstitution of MRGPRD in heterologous systems has provided insights into its pharmacological properties, aiding in the identification of selective ligands. Given the receptor's unique expression profile and functional characteristics, MRGPRD represents a promising target for novel drug development aimed at alleviating conditions associated with chronic pain and pruritus, thereby highlighting its relevance in both basic research and clinical applications.
