Analytical Data
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Gene name
MPHOSPH8
- Application
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Alternative Names
HSMPP8; M-phase phosphoprotein 8; M-phase phosphoprotein. mpp; M-phase phosphoprotein. mpp8; MPHOSPH8; MPP8_HUMAN; RP11-523H24.1; Twa3; Two hybrid-associated protein 3 with RanBPM
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99549
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Expression Region
1-259 aa
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AA Sequence
MTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYRVQLQ
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Molecular Weight
54.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MPHOSPH8, a member of the MPHOSPH protein family, has emerged as a significant protein in various cellular processes, particularly in relation to cell proliferation and cancer biology. This protein is believed to play a crucial role in regulating the mitotic phase of the cell cycle and maintaining chromosome stability, which are vital for accurate cell division. Research has shown that MPHOSPH8 interacts with several key proteins involved in cell cycle regulation and DNA repair, suggesting its potential as a regulatory hub in these processes. Furthermore, alterations in MPHOSPH8 expression have been linked to various malignancies, raising interest in its role as a biomarker for cancer diagnosis and prognosis. Investigating the structure and function of MPHOSPH8, particularly through the development of recombinant protein forms, can provide crucial insights into its mechanisms of action and therapeutic potential. Understanding how MPHOSPH8 contributes to cellular pathology could open new avenues for targeted cancer therapies, making it a focal point of current biomedical research aimed at addressing malignancies associated with aberrations in the cell cycle.
