Analytical Data
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Gene name
MRGPRX2
- Application
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Alternative Names
MRGPRX2；MRGX2；Mas-related G-Protein coupled receptor member X2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96LB1
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Expression Region
1-330aa
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AA Sequence
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
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Molecular Weight
43.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRGPRX2, a member of the Mas-related gene (MRG) family, is a G-protein coupled receptor predominantly expressed in mast cells and sensory neurons. It has garnered significant interest in recent years due to its role in mediating various physiological processes, including pain sensation, allergic responses, and neurogenic inflammation. Dysregulation or aberrant activation of MRGPRX2 has been implicated in several pathological conditions, such as chronic pain syndromes, allergic diseases, and asthma. Understanding the molecular mechanisms underlying MRGPRX2 signaling pathways could offer new therapeutic targets for these conditions. Research on recombinant MRGPRX2 proteins enables detailed investigations into the receptor's structure-function relationships, ligand interactions, and downstream signaling cascades. By producing and characterizing MRGPRX2 recombinant proteins, researchers can elucidate how specific ligands, such as neuropeptides and small molecules, activate the receptor, thereby contributing to the advancement of targeted therapies for diseases influenced by MRGPRX2. This research not only enhances our understanding of MRGPRX2 biology but also holds potential for the development of novel pharmacological agents aimed at modulating its activity in various clinical settings.
