Analytical Data
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Gene name
MOBKL1A
- Application
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Alternative Names
MATS 2; MATS2; MGC33910; Mob 1A; Mob 1B; MOB 4A; MOB kinase activator 1B; Mob1 homolog 1A; MOB1 Mps One Binder homolog B; MOB1 Mps one binder kinase activator like 1A; Mob1A; Mob1B; MOBKL 1A; MOBKL1A; MOL1A_HUMAN; Mps one binder kinase activator like 1A; Mps one binder kinase activator-like 1A; Protein Mob4A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7L9L4
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Expression Region
2-216 aa
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AA Sequence
SFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG EDLNEWVAVN TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LTSKDR
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Molecular Weight
25.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MOBKL1A, or MOB kinase activator 1A, is a member of the MOB1 protein family, which plays a crucial role in cellular processes such as cell growth, division, and apoptosis by acting as a co-activator for the Hippo signaling pathway. The Hippo pathway is vital for regulating organ size and preventing tumorigenesis, making MOBKL1A a significant protein in cancer research. Dysregulation of this pathway has been linked to various cancers, highlighting the importance of understanding the molecular mechanisms involving MOBKL1A. Recent studies have shown that MOBKL1A interacts with several key proteins, including LATS kinases, thereby influencing the phosphorylation state of downstream effectors. The production of recombinant MOBKL1A protein has become essential for elucidating its structure-function relationship and for exploring its role in the Hippo pathway. By generating this recombinant protein, researchers can conduct detailed biochemical assays, structural analyses, and functional studies, which will advance our understanding of its regulatory mechanisms and potential implications in cancer therapy. The exploration of MOBKL1A's role at a molecular level is expected to contribute significantly to the development of targeted therapies and provide insights into novel treatment strategies for malignancies associated with dysregulated Hippo signaling. Through these studies, MOBKL1A emerges not only as a critical player in cell signaling but also as a potential biomarker and therapeutic target in oncology.
