Analytical Data
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Gene name
PTPRN2
- Application
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Alternative Names
PTPRN2；KIAA0387；Receptor-type tyrosine-Protein phosphatase N2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92932
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Expression Region
22-615aa
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AA Sequence
AAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKF
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Molecular Weight
66.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPRN2 (Protein Tyrosine Phosphatase Receptor Type N2) is a member of the receptor-type protein tyrosine phosphatase (RPTP) family, which plays a crucial role in various cellular processes including cell signaling, development, and immune response. Dysregulation or mutations in PTPRN2 have been implicated in several diseases, particularly in autoimmune disorders and certain types of cancer. Research has highlighted its significance in neuronal signaling and its role in insulin secretion and glucose metabolism, making it a potential target for therapeutic intervention in diabetes. As a receptor-type phosphatase, PTPRN2 is involved in the dephosphorylation of tyrosine residues, influencing pathways that regulate cell growth and differentiation. The study of recombinant PTPRN2 proteins provides valuable insights into its structure-function relationships and interactions with other cellular components. Understanding the biochemical properties and functional implications of PTPRN2 can contribute to the development of novel strategies for treating diseases associated with its dysfunction. Furthermore, the characterization of this protein in recombinant forms is essential for studying its enzymatic activity, substrate specificity, and potential as a biomarker in disease contexts. Overall, research into PTPRN2 and its recombinant proteins holds promise for advancing our knowledge of cell signaling mechanisms and developing targeted therapies for associated pathologies.
