Analytical Data
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Gene name
MORC4
- Application
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Alternative Names
MORC4；ZCW4；ZCWCC2；MORC family CW-type zinc finger Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TE76
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Expression Region
29-486aa
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AA Sequence
GIRLSTMSPRYLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMIITEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQYDILVSDFDTEEKMTGGVTSELPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIAKSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFETSTVARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQELTDEDLCLSKAKKQE
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Molecular Weight
57.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MORC4 (Microrchidia 4) is a relatively newly identified member of the MORC family of proteins, which are known for their roles in chromatin remodeling and gene regulation. Research into MORC4 has gained momentum due to its essential functions in cellular processes, including DNA repair, transcriptional regulation, and early development. Preliminary studies have suggested that MORC4 is involved in maintaining genome stability, particularly under stress conditions, indicating its potential role in cancer biology and response to therapies. Additionally, MORC4 has been implicated in various developmental processes, making it a candidate for studying developmental disorders and other diseases. Despite its significance, the full range of MORC4's functions and mechanisms of action remains largely unexplored. Investigating MORC4's biochemical properties and its interactions with other cellular components could provide insights into its role in health and disease. This highlights the need for more focused studies on MORC4, aiming to elucidate its functions and therapeutic potential, particularly in cancer treatment strategies where gene regulation plays a critical role. Understanding MORC4's contributions to cellular mechanics could offer new avenues for therapeutic intervention in various diseases, emphasizing its importance in the field of molecular biology and medicine.
