Analytical Data
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基因名
PIP4K2B
- Application
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别名
PIP4K2A;PI5P4KA;PIP5K2;PIP5K2A;Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P78356
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表达区间
2-416aa
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氨基酸序列
SSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
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分子量
53.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIP4K2B, or phosphoinositide-5-phosphate 4-kinase type 2 beta, is an essential member of the phosphoinositide kinase family, which plays a pivotal role in cellular signaling and membrane trafficking. This enzyme is primarily involved in the phosphorylation of phosphatidylinositol 5-phosphate (PI5P) to produce phosphatidylinositol 4,5-bisphosphate (PIP2), a critical lipid that acts as a signaling molecule influencing various cellular processes, including growth, survival, and motility. Research into PIP4K2B has gained traction due to its implications in several pathophysiological conditions, such as cancer, metabolic disorders, and neurodegenerative diseases. Notably, alterations in PIP4K2B expression and activity have been associated with tumorigenesis and tumor progression, emphasizing its potential as a therapeutic target. Furthermore, PIP4K2B has been implicated in the regulation of autophagy and endocytosis, cellular processes that are vital for maintaining cellular homeostasis. As scientists continue to unravel the biochemical pathways and cellular mechanisms involving PIP4K2B, the recombinant protein becomes an invaluable tool for elucidating its functional roles and exploring its potential applications in targeted therapies. Consequently, studying PIP4K2B not only enhances our understanding of lipid signaling pathways but also opens new avenues for innovative treatments for various diseases.
