Analytical Data
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基因名
CAMK2D
- Application
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别名
CAMK2D；CAMKD；Calcium/calmodulin-dependent Protein kinase type II subunit delta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13557
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表达区间
2-499aa
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氨基酸序列
ASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
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分子量
63.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAMK2D (Calcium/Calmodulin-dependent Protein Kinase II Delta) is a member of the CAMK2 family, which plays a crucial role in various cellular processes, including calcium signaling, synaptic plasticity, and muscle function. Due to its involvement in critical cellular functions, CAMK2D has garnered significant attention in the context of cardiovascular diseases, neurodegenerative disorders, and cancer. Research has shown that CAMK2D is activated by calcium and calmodulin, leading to its phosphorylation of various substrates that regulate important signaling pathways. The dysregulation of CAMK2D activity has been implicated in pathological conditions, such as heart failure and neuronal excitotoxicity. The recombinant protein of CAMK2D is essential for understanding its biochemical properties and functional mechanisms. By producing and purifying CAMK2D through recombinant DNA technology, researchers can analyze the enzyme's activity, substrate specificity, and regulatory mechanisms in vitro. Furthermore, the recombinant protein enables the development of pharmacological inhibitors, which may provide therapeutic avenues for diseases linked to CAMK2D dysregulation. Through these studies, scientists aim to elucidate the complexities of CAMK2D signaling and its role in health and disease, ultimately paving the way for novel treatment strategies targeting this important kinase.
