Analytical Data
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Gene name
CAMK2D
- Application
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Alternative Names
CAMK2D；CAMKD；Calcium/calmodulin-dependent Protein kinase type II subunit delta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13557
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Expression Region
2-499aa
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AA Sequence
ASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
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Molecular Weight
63.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAMK2D (Calcium/Calmodulin-dependent Protein Kinase II Delta) is a member of the CAMK2 family, which plays a crucial role in various cellular processes, including calcium signaling, synaptic plasticity, and muscle function. Due to its involvement in critical cellular functions, CAMK2D has garnered significant attention in the context of cardiovascular diseases, neurodegenerative disorders, and cancer. Research has shown that CAMK2D is activated by calcium and calmodulin, leading to its phosphorylation of various substrates that regulate important signaling pathways. The dysregulation of CAMK2D activity has been implicated in pathological conditions, such as heart failure and neuronal excitotoxicity. The recombinant protein of CAMK2D is essential for understanding its biochemical properties and functional mechanisms. By producing and purifying CAMK2D through recombinant DNA technology, researchers can analyze the enzyme's activity, substrate specificity, and regulatory mechanisms in vitro. Furthermore, the recombinant protein enables the development of pharmacological inhibitors, which may provide therapeutic avenues for diseases linked to CAMK2D dysregulation. Through these studies, scientists aim to elucidate the complexities of CAMK2D signaling and its role in health and disease, ultimately paving the way for novel treatment strategies targeting this important kinase.
