Analytical Data
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Gene name
ACACb
- Application
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Alternative Names
ACACb；ACC2；ACCB；Acetyl-CoA carboxylase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00763
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
276.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ACACb (acetyl-CoA carboxylase beta) is a critical enzyme that plays a significant role in fatty acid metabolism and energy homeostasis. It catalyzes the conversion of acetyl-CoA to malonyl-CoA, a key step in fatty acid biosynthesis and regulation of mitochondrial fatty acid oxidation. Dysregulation of ACACb is linked to various metabolic disorders, including obesity, insulin resistance, and cardiovascular diseases. Given its central role in metabolic pathways, ACACb is an attractive target for therapeutic interventions aimed at treating these conditions. Recent advances in molecular biology and protein engineering have enabled the production of recombinant ACACb, facilitating detailed studies of its structure, function, and regulatory mechanisms. Researchers have focused on understanding the enzyme's allosteric regulation and post-translational modifications, which influence its activity and stability. Moreover, recombinant ACACb serves as a valuable tool for drug discovery, allowing for high-throughput screening of potential inhibitors that could modulate its activity. This research not only enhances our understanding of metabolic regulation but also paves the way for novel therapeutic strategies to combat metabolic diseases linked to ACACb dysfunction.
