Analytical Data
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Gene name
PINX1
- Application
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Alternative Names
PINX1;LPTL;LPTS;PIN2/TERF1-interacting telomerase inhibitor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96BK5
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Expression Region
1-328aa
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AA Sequence
MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEQ GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKRNKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PINX1, also known as PIN2/TERF1-interacting protein, has emerged as a significant player in the regulation of telomere maintenance and cellular responses to stress. The role of PINX1 in cancer biology has attracted considerable attention, as it functions as a telomerase inhibitor, thereby playing a crucial part in cellular aging and tumorigenesis. Studies have indicated that overexpression of PINX1 can lead to telomere shortening, which might impede the unlimited proliferation of cancer cells. Investigating PINX1 through recombinant protein studies allows researchers to elucidate its structural properties, interaction with telomerase components, and overall impact on telomere dynamics. Furthermore, understanding the functional mechanisms of PINX1 could reveal potential therapeutic targets for cancer treatment, especially in tumors where telomerase activity is dysregulated. Recent advancements in protein engineering techniques have facilitated the production of high-purity recombinant PINX1, enabling comprehensive biochemical and biophysical analyses. Through such studies, researchers aim to decipher the precise role of PINX1 in telomere biology and its implications in disease pathology. This growing body of work underscores the importance of PINX1 as a molecular regulator, potentially paving the way for novel strategies in oncology and regenerative medicine.
