Analytical Data
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基因名
METTL5
- Application
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别名
2810410A08Rik; DC3; FLJ10459; HSPC133; mCG_12967; Methyltransferase like protein 5; Methyltransferase-like protein 5; METL5_HUMAN; METTL 5; METTL5; MGC187943; OTTHUMP00000205107; OTTHUMP00000205108; OTTHUMP00000205109; OTTMUSP00000040951; RGD1566062
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NRN9
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表达区间
1-209 aa
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氨基酸序列
MKKVRLKELE SRLQQVDGFE KPKLLLEQYP TRPHIAACML YTIHNTYDDI ENKVVADLGC GCGVLSIGTA MLGAGLCVGF DIDEDALEIF NRNAEEFELT NIDMVQCDVC LLSNRMSKSF DTVIMNPPFG TKNNKGTDMA FLKTALEMAR TAVYSLHKSS TREHVQKKAA EWKIKIDIIA ELRYDLPASY KFHKKKSVDI EVDLIRFSF
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分子量
23.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
METTL5 is a methyltransferase enzyme that plays a critical role in the post-transcriptional modification of RNA. It is known to specifically catalyze the N6-methyladenosine (m6A) modification, a crucial epitranscriptomic mark that influences various aspects of RNA metabolism, including splicing, stability, translation, and degradation. Recent studies suggest that METTL5 is involved in regulating gene expression and cellular processes, with implications in development, differentiation, and disease progression. The dysfunction of m6A modifications, particularly through dysregulation of METTL5, has been linked to numerous disorders, including cancer and neurological diseases. As research progresses, understanding the molecular mechanisms through which METTL5 operates could provide insights into therapeutic targets and strategies for manipulating RNA modifications in disease contexts. Given its significance, the recombinant production of METTL5 is crucial for conducting structural and functional studies, enabling researchers to explore its enzymatic activity, substrate specificity, and interactions with other cellular factors. This knowledge can further elucidate the role of METTL5 in the intricate regulatory networks governing RNA metabolism and offer potential avenues for biotechnological and clinical applications.
