Analytical Data
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Gene name
PTPN5
- Application
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Alternative Names
PTPN5；Tyrosine-Protein phosphatase non-receptor type 5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P54829
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Expression Region
1-565aa
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AA Sequence
MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQ DSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLAC GVLWFSGYGHIWSQNATNLVSSLLTLLKQLEPTAWLDSGTWGVPSLLLVF LSVGLVLVTTLVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEK IEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLT LDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLL QAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPL SSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN IEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERG LKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGI GRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHH VMSLYEKQLSHQSPE
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Molecular Weight
90 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPN5, also known as Protein Tyrosine Phosphatase, Non-Receptor Type 5, is an essential enzyme involved in multiple cellular processes, including signal transduction, cell differentiation, and immune response. Research into PTPN5 has gained momentum due to its potential implications in various diseases, particularly in cancer and neurodegenerative disorders. The protein is known for its role in regulating phosphorylated proteins, thereby modulating pathways critical for cell growth and survival. The abnormal expression or activity of PTPN5 has been implicated in tumor progression, making it a candidate for therapeutic interventions. Recombinant PTPN5 protein studies allow for the exploration of its structure-function relationships and provide insight into its role in signaling pathways. Additionally, understanding the detailed molecular mechanisms of PTPN5 can inform drug development efforts targeting diseases associated with its dysregulation. Scientists are utilizing advanced techniques such as gene cloning, expression systems, and biochemical assays to produce and study PTPN5, contributing to a better understanding of its biological functions and potential as a drug target. As research progresses, the recombinant PTPN5 protein serves as a valuable tool in both basic and applied biomedical research, paving the way for novel treatment strategies in disease management.
