Analytical Data
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Gene name
OXSR1
- Application
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Alternative Names
OXSR1;KIAA1101;OSR1;Serine/threonine-Protein kinase OSR1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95747
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Expression Region
1-527aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMSEDSSALPWSINRDDYELQEVIGSGA TAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVS YYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATIL REVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDI TRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPY HKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPE KRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGR LHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDP VGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGS QETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGR DLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
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Molecular Weight
60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
OXSR1, or oxidative stress-responsive kinase 1, is a serine/threonine protein kinase that plays a crucial role in cellular responses to oxidative stress and maintains cellular homeostasis. Research has shown that OXSR1 is involved in various physiological processes, including regulating ion transport, cell proliferation, and apoptosis under stress conditions. Its activity is linked to key signaling pathways that respond to environmental stressors, making it a significant protein in understanding cellular adaptations that can influence diseases such as cancer and neurodegenerative disorders. In recent years, scientists have focused on characterizing the structure and function of the OXSR1 protein, particularly its kinase domain, to uncover mechanisms of action and potential therapeutic targets. The production of recombinant OXSR1 proteins has facilitated biochemical studies and functional assays, providing insights into the protein’s role in mediating cellular responses to oxidative stress. Additionally, understanding the interactions between OXSR1 and its substrates has important implications for developing strategies to modulate its activity in disease contexts. Overall, the ongoing research on OXSR1 is vital for uncovering its contributions to cellular signaling networks and developing novel therapeutic approaches for stress-related diseases.
