Analytical Data
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Gene name
OXSM
- Application
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Alternative Names
OXSM;3-oxoacyl-[acyl-carrier-Protein] synthase. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NWU1
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Expression Region
28-459aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSKRKFFGTVPISRLHRRVVITGIGLVTP LGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSDEGQFNEQ NFVSKSDIKSMSSPTIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGM IPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHA VSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARAL STNSDPKLACRPFHPKRDGFVMGEGAAVLVLEEYEHAVQRRARIYAEVLG YGLSGDAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPL GDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYY QKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEKRFIGLTNSFGFGGTNATL CIAGL
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Molecular Weight
48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OXSM (Oxidation Resistance 1 Protein) is a relatively novel protein that plays a crucial role in cellular stress responses, particularly under oxidative stress conditions. Research into OXSM has gained momentum due to growing evidence linking oxidative stress to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Oxidative stress occurs when there’s an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them, leading to cellular damage. OXSM is believed to enhance cellular resistance to oxidative damage by modulating antioxidant pathways and cellular repair mechanisms. Recent studies have demonstrated that OXSM expression increases in response to oxidative stress, suggesting its potential role as a protective factor in maintaining cellular homeostasis. Given its significance, the recombinant expression and characterization of OXSM have become pivotal in understanding its biochemical properties and functions. Researchers aim to produce recombinant OXSM proteins to study their structural and functional characteristics in vitro, elucidate their interaction with other cellular components, and evaluate their potential therapeutic applications in combating oxidative stress-related diseases. This research could pave the way for the development of novel antioxidant therapies targeting OXSM pathways, ultimately contributing to improved health outcomes and disease management strategies.
