Analytical Data
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Gene name
GJD2
- Application
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Alternative Names
GJD2；GJA9；Gap junction delta-2 Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UKL4
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Expression Region
1-321aa
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AA Sequence
MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNKDLPRVSVPNFGRTQSSDSAYV
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Molecular Weight
36.2kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GJD2, also known as Gap Junction Protein Delta 2, plays a crucial role in intercellular communication by forming gap junctions that allow the direct exchange of ions and small molecules between adjacent cells. This protein is particularly important in various biological processes, including cardiac and neural function, where precise cellular signaling is vital. Abnormalities in GJD2 expression or function have been implicated in a range of diseases, such as cardiac arrhythmias and neurological disorders. The recombinant production of GJD2 protein is essential for studying its structural and functional properties, as well as for understanding its interactions with other cellular components. Researchers utilize techniques such as molecular cloning, expression in suitable host systems (like E. coli or yeast), and purification protocols to obtain functional GJD2 protein. This enables detailed investigations into its role in gap junction formation, regulation, and its potential as a therapeutic target. Understanding the mechanisms governing GJD2 function can provide insights into the pathophysiology of associated diseases and pave the way for developing innovative treatments aimed at modulating gap junction communication. Overall, the study of GJD2 recombinant protein is fundamental to advancing our knowledge of cell communication and its implications in health and disease.
