Analytical Data
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基因名
TIPARP
- Application
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别名
TIPARP；PARP7；Protein mono-ADP-ribosyltransferase TIPARP
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
TIPARP
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表达区间
1-657aa
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氨基酸序列
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPILNTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQIPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDKVIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDRMRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREYPESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
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分子量
82.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
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Recombinant Human TRPV6 Protein，His
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Protein Description
TIPARP (TCDD-Inducible Poly(ADP-ribose) Polymerase) is a member of the poly(ADP-ribose) polymerase (PARP) family, which plays a crucial role in cellular responses to DNA damage and stress. The enzyme was first identified due to its inducibility by toxic environmental pollutants, particularly dioxins, which are known to interfere with cellular signaling and homeostasis. Research has revealed that TIPARP is involved in various cellular processes, including gene regulation, cellular stress response, and inflammation. Its ability to modify proteins through ADP-ribosylation suggests a pivotal role in modulating signaling pathways pertinent to tumorigenesis and autoimmune diseases. Furthermore, TIPARP has been shown to exhibit anti-apoptotic effects, which may have implications for cancer therapy and understanding the mechanisms of resistance to chemotherapy. The growing interest in TIPARP as a potential therapeutic target has led to the exploration of its structural properties, functional mechanisms, and interactions with other cellular molecules, positioning it as a critical focus in the field of molecular biology and pharmacology. Researchers are particularly interested in the development of TIPARP inhibitors, which could pave the way for novel treatment strategies in cancer and other diseases linked to dysregulated ADP-ribosylation. As the understanding of TIPARP's role expands, its significance in health and disease continues to motivate further investigation into its potential applications in precision medicine.
