Analytical Data
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基因名
MAGEA11
- Application
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别名
MAGEA11; MAGE11Melanoma-associated antigen 11; Cancer/testis antigen 1.11; CT1.11; MAGE-11 antigen
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43364
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表达区间
1-429aa
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氨基酸序列
METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY GPQLQWSQDL PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT VRPADLTRVI MPLEQRSQHC KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF FSSTLNVGTL EELPAAESPS PPQSPQEESF SPTAMDAIFG SLSDEGSGSQ EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK GLITKAEMLG SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF LFGEPKRLLT QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL EYIANANGRD PTSYPSLYED ALREEGEGV
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分子量
48.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAGEA11 (Melanoma Antigen Gene A11) is a member of the MAGE (Melanoma Antigen Gene) family, which encodes tumor-associated antigens that are primarily expressed in malignant cells but not in normal tissues, making them potential targets for cancer immunotherapy. Research on MAGEA11 has gained significant attention due to its implication in various cancers, including melanoma, breast cancer, and prostate cancer. The protein is involved in important cellular processes, including apoptosis and gene regulation, which contribute to tumorigenesis. Recombinant MAGEA11 proteins are being developed for use in diagnostic assays and therapeutic applications, as they can elicit specific immune responses in patients. Additionally, understanding the structure and function of MAGEA11 is crucial for the design of effective vaccines and monoclonal antibodies. Advances in protein engineering and expression systems have facilitated the production of high-purity MAGEA11 recombinant proteins, allowing researchers to investigate their immunogenicity and therapeutic potential in preclinical studies. The exploration of MAGEA11 not only enhances our comprehension of tumor biology but also expands the arsenal of tools available for cancer diagnosis and treatment, positioning it as a promising candidate in personalized cancer immunotherapy regimens.
