Analytical Data
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Gene name
MAGEA11
- Application
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Alternative Names
MAGEA11; MAGE11Melanoma-associated antigen 11; Cancer/testis antigen 1.11; CT1.11; MAGE-11 antigen
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43364
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Expression Region
1-429aa
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AA Sequence
METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY GPQLQWSQDL PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT VRPADLTRVI MPLEQRSQHC KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF FSSTLNVGTL EELPAAESPS PPQSPQEESF SPTAMDAIFG SLSDEGSGSQ EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK GLITKAEMLG SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF LFGEPKRLLT QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL EYIANANGRD PTSYPSLYED ALREEGEGV
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Molecular Weight
48.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAGEA11 (Melanoma Antigen Gene A11) is a member of the MAGE (Melanoma Antigen Gene) family, which encodes tumor-associated antigens that are primarily expressed in malignant cells but not in normal tissues, making them potential targets for cancer immunotherapy. Research on MAGEA11 has gained significant attention due to its implication in various cancers, including melanoma, breast cancer, and prostate cancer. The protein is involved in important cellular processes, including apoptosis and gene regulation, which contribute to tumorigenesis. Recombinant MAGEA11 proteins are being developed for use in diagnostic assays and therapeutic applications, as they can elicit specific immune responses in patients. Additionally, understanding the structure and function of MAGEA11 is crucial for the design of effective vaccines and monoclonal antibodies. Advances in protein engineering and expression systems have facilitated the production of high-purity MAGEA11 recombinant proteins, allowing researchers to investigate their immunogenicity and therapeutic potential in preclinical studies. The exploration of MAGEA11 not only enhances our comprehension of tumor biology but also expands the arsenal of tools available for cancer diagnosis and treatment, positioning it as a promising candidate in personalized cancer immunotherapy regimens.
