Analytical Data
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Gene name
MAFB
- Application
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Alternative Names
Kreisler; Kreisler (mouse) maf related leucine zipper homolog; Kreisler maf related leucine zipper homolog; KRML; MAF bZIP transcription factor B; Maf-B; Mafb; MAFB/Kreisler basic region/leucine zipper transcription factor; MAFB_HUMAN; MGC43127; Segmentation protein KR; Transcription factor MafB; V maf musculoaponeurotic fibrosarcoma oncogene homolog B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5Q3
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Expression Region
1-323aa
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AA Sequence
MAAELSMGPE LPTSPLAMEY VNDFDLLKFD VKKEPLGRAE RPGRPCTRLQ PAGSVSSTPL STPCSSVPSS PSFSPTEQKT HLEDLYWMAS NYQQMNPEAL NLTPEDAVEA LIGSHPVPQP LQSFDSFRGA HHHHHHHHPH PHHAYPGAGV AHDELGPHAH PHHHHHHQAS PPPSSAASPA QQLPTSHPGP GPHATASATA AGGNGSVEDR FSDDQLVSMS VRELNRHLRG FTKDEVIRLK QKRRTLKNRG YAQSCRYKRV QQKHHLENEK TQLIQQVEQL KQEVSRLARE RDAYKVKCEK LANSGFREAG STSDSPSSPE FFL
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Molecular Weight
35.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAFB, or transcription factor MAFB, belongs to the MAF protein family and plays a critical role in various physiological processes, particularly in cellular differentiation, immune response, and organ development. It is highly expressed in specific tissues, such as the pancreas, where it influences the differentiation of insulin-producing beta cells, making it a focal point of research in diabetes and metabolic disorders. Additionally, MAFB is implicated in the regulation of immune cells, particularly macrophages, contributing to inflammation and tissue homeostasis. Given its diverse roles, the study of MAFB recombinant proteins has gained traction in recent years to understand its functions better and explore potential therapeutic applications. Researchers aim to elucidate MAFB's interactions with other cellular proteins and its downstream signaling pathways. Investigations into MAFB's role in tumorigenesis have also emerged, as altered expression levels of MAFB have been linked to various cancers, prompting further exploration of its potential as a biomarker or therapeutic target. Overall, the reconstitution of MAFB as a recombinant protein serves as a crucial tool for advancing our understanding of its molecular mechanisms and exploring its possibilities in regenerative medicine, immunotherapy, and cancer treatment.
