Analytical Data
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Gene name
LUC7L
- Application
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Alternative Names
LUC7L; LUC7L1Putative RNA-binding protein Luc7-like 1; Putative SR protein LUC7B1; SR+89
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQ29
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Expression Region
1-325aa
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AA Sequence
MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKLSRSRSRDRHRRHRSRSRSHSRGHRRASRDRSAKYK
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Molecular Weight
64.8 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LUC7L, a member of the LUC7 family of proteins, plays a crucial role in the regulation of gene expression and RNA processing, particularly in the context of pre-mRNA splicing. This protein is characterized by the presence of specific RNA-binding domains, which enable it to interact with various components of the spliceosome and influence splicing efficiency and specificity. Recent studies have highlighted the importance of LUC7L in various cellular processes, including cell proliferation, differentiation, and response to stress, making it a significant focus of research in molecular biology and genetics. The ability to produce recombinant LUC7L protein has facilitated in-depth studies of its structural and functional properties, enabling researchers to explore its mechanisms of action and potential implications in diseases associated with splicing defects, such as cancer and genetic disorders. Additionally, understanding LUC7L's role in alternative splicing pathways may provide insights into the regulation of gene expression in different physiological contexts. As a result, the investigation of LUC7L recombinant protein offers promising avenues for developing therapeutic strategies that can target splicing abnormalities and enhance our understanding of post-transcriptional regulation in eukaryotic cells.
